Peptide and Macrocycle Drug Design

Peptide and Macrocycle Drug Design explores the growing field of designing therapeutics based on peptides and cyclic molecules, which offer high specificity and affinity for challenging biological targets. This session highlights strategies for improving the stability, permeability, and bioavailability of peptide-based drugs, as well as computational methods for modeling their complex structures. Topics include macrocyclization techniques, structure-activity relationships, and the design of constrained peptides for targeting protein–protein interactions. Advances in synthetic approaches and delivery systems will also be discussed, showcasing the therapeutic potential of these versatile molecules.
• Computational strategies for peptide optimization
• Cyclic peptide modeling and docking
• Challenges in cell permeability and stability

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