Modern Strategies in Lead Identification and Optimization
Modern Strategies in Lead Identification and Optimization focuses on innovative approaches used to discover and refine chemical compounds with therapeutic potential. This session explores how advances in high-throughput screening, fragment-based drug discovery, and computational modeling have accelerated the identification of initial hits. It also delves into lead optimization techniques such as structure-activity relationship (SAR) analysis, bio isosteric replacement, and property-based design to enhance potency, selectivity, and drug-like properties. Emphasis is placed on integrating multidisciplinary tools, including AI, structural biology, and cheminformatics, to streamline the path from hit to high-quality clinical candidate.
• High-Throughput and Fragment-Based Screening Techniques
• Structure-Activity Relationship (SAR) and Lead Refinement
• Bioisosterism and Scaffold Hopping in Lead Optimization
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Modern Strategies in Lead Identification and Optimization Conference Speakers
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