EPR effect for cancer and inflammation
The field of nanomedicine, despite being conceptualized as far back as the 1980’s, is only now transitioning in a broad sense from academic research to drug development and commercialization. In oncology, unique structural features of many solid tumors including hyper-vasculature, defective vascular architecture, and impaired lymphatic drainage leading to the well characterized enhanced permeability and retention (EPR) effect are key factors in advancing this platform technology. However, the EPR effect has been measured mostly if not exclusively in implanted tumors with limited data on EPR in metastatic lesions in both mice and patients
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