Bio isosteres

In medicinal chemistry, bio isosteres are chemical substituents or groups with similar physical or chemical properties which produce largely similar biological properties to alternative chemical compound. In drug design, the purpose of exchanging one bio isostere for another is to increase the desired biological or physical properties of a compound without making substantial deviations in chemical structure. The main research of this term and its techniques are related to pharmaceutical sciences. Bio isosterism is used to condense toxicity, change bioavailability, or alter the activity of the lead compound, and may modify the metabolism of the lead.


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